Interrogation of the microenvironmental landscape in spinal ependymomas reveals dual functions of tumor-associated macrophages
oleh: Qianqian Zhang, Sijin Cheng, Yongzhi Wang, Mengdi Wang, Yufeng Lu, Zengqi Wen, Yuxin Ge, Qiang Ma, Youqiao Chen, Yaowu Zhang, Ren Cao, Min Li, Weihao Liu, Bo Wang, Qian Wu, Wenqing Jia, Xiaoqun Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-11-01 |
Deskripsi
The intratumoural heterogeneity of spinal ependymomas and the role of microglia in tumour progression remain underexplored. Here, the authors perform single-cell RNA- and ATAC-sequencing data analysis of three subtypes and reveal tumour-associated macrophage subsets with distinct functional phenotypes.