Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Nanoscale Two-Dimensional Fe<sup>II</sup>- and Co<sup>II</sup>-Based Metal–Organic Frameworks of Porphyrin Ligand for the Photodynamic Therapy of Breast Cancer
oleh: Qing Li, Bo-Wei Xu, Yi-Ming Zou, Ru-Jie Niu, Jin-Xiang Chen, Wen-Hua Zhang, David James. Young
Format: | Article |
---|---|
Diterbitkan: | MDPI AG 2023-02-01 |
Deskripsi
The delivery of biocompatible reagents into cancer cells can elicit an anticancer effect by taking advantage of the unique characteristics of the tumor microenvironment (TME). In this work, we report that nanoscale two-dimensional Fe<sup>II</sup>- and Co<sup>II</sup>-based metal–organic frameworks (NMOFs) of porphyrin ligand meso-tetrakis (6-(hydroxymethyl) pyridin-3-yl) porphyrin (THPP) can catalyze the generation of hydroxyl radicals (•OH) and O<sub>2</sub> in the presence of H<sub>2</sub>O<sub>2</sub> that is overexpressed in the TME. Photodynamic therapy consumes the generated O<sub>2</sub> to produce a singlet oxygen (<sup>1</sup>O<sub>2</sub>). Both •OH and <sup>1</sup>O<sub>2</sub> are reactive oxygen species (ROS) that inhibit cancer cell proliferation. The Fe<sup>II</sup>- and Co<sup>II</sup>-based NMOFs were non-toxic in the dark but cytotoxic when irradiated with 660 nm light. This preliminary work points to the potential of porphyrin-based ligands of transition metals as anticancer drugs by synergizing different therapeutic modalities.