L-selectin mechanochemistry restricts neutrophil priming in vivo
oleh: Zhenghui Liu, Tadayuki Yago, Nan Zhang, Sumith R. Panicker, Ying Wang, Longbiao Yao, Padmaja Mehta-D’souza, Lijun Xia, Cheng Zhu, Rodger P. McEver
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-05-01 |
Deskripsi
Neutrophil adhesion is tightly regulated to enforce protective immunity, but it is unclear how mechanochemical processes such as catch bonds and slip bonds modulate neutrophilsin vivo. Here the authors show that a point mutation in the adhesion molecule L-selectin alters mechanochemical regulation to affect neutrophil functions in mice.