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In order to study the law of instability and failure in the process of loading of the south dumping site of Hesgoola Coal Mine, the FLAC 3D numerical simulation experiment and the bottom friction simulation experiment were carried out for the deformation and failure of the slope of the south dumping site, the law of instability and failure in the process of loading of south dumping site is obtained, and the relevant safety precontrol measures and suggestions are put forward. This is of great significance to ensure the safety production of the south dumping site of Hesgoola Coal Mine.