Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection
oleh: Serena Vita, Paola Zuccalà , Stefano Savinelli, Claudia Mascia, Raffaella Rossi, Francesco Schiavone, Raffaella Marocco, Tiziana Tieghi, Marco Iannetta, Parni Nijhawan, Maria Antonella Zingaropoli, Gabriella d’Ettore, Vincenzo Vullo, Claudio Maria Mastroianni, Miriam Lichtner
| Format: | Article |
|---|---|
| Diterbitkan: | Hindawi Limited 2020-01-01 |
Deskripsi
Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.