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In the third quarter of 2017, culprit only percutaneous coronary intervention (PCI) fares better in acute myocardial infarction with shock, guided de-escalation antiplatelet therapy seems noninferior, drug-eluting stent (DES) better in elderly patients undergoing PCI, DES with ultrathin struts proves superior, atrial fibrillation ablation improves left ventricular function in idiopathic cardiomyopathy, and edoxaban beneficial in preventing cancer-associated venous thromboembolism.