INPP4B protects from metabolic syndrome and associated disorders
oleh: Manqi Zhang, Yasemin Ceyhan, Elena M. Kaftanovskaya, Judy L. Vasquez, Jean Vacher, Filip K. Knop, Lubov Nathanson, Alexander I. Agoulnik, Michael M. Ittmann, Irina U. Agoulnik
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-03-01 |
Deskripsi
Characterizing mice lacking Inositol Polyphosphate-4-Phosphatase Type II B (INPP4B), Zhang et al. discovered that SREBP1 signaling is activated in livers of Inpp4b −/− males leading to development of NAFLD and insulin resistance. When fed high fat diet, Inpp4b −/− males develop type II diabetes, inflammation of adipose tissue, and prostate neoplasia. These findings provide insights into INPP4B protective role from metabolic syndrome.