A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation

oleh: Jeannette Reinig, Frank Ruge, Martin Howard, Leonie Ringrose

Format: Article
Diterbitkan: Nature Portfolio 2020-09-01

Deskripsi

Polycomb (PcG) and Trithorax (TrxG) group regulate several hundred target genes with important roles in development and disease. Here the authors combine experiment and theory to provide evidence that the Polycomb/Trithorax system has the potential for a rich repertoire of regulatory modes beyond simple epigenetic memory.