Mutational spectrum of Barrett’s stem cells suggests paths to initiation of a precancerous lesion
oleh: Yusuke Yamamoto, Xia Wang, Denis Bertrand, Florian Kern, Ting Zhang, Marcin Duleba, Supriya Srivastava, Chiea Chuen Khor, Yuanyu Hu, Lane H. Wilson, Hagen Blaszyk, Daniil Rolshud, Ming Teh, Jianjun Liu, Brooke E. Howitt, Matthew Vincent, Christopher P. Crum, Niranjan Nagarajan, Khek Yu Ho, Frank McKeon, Wa Xian
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2016-01-01 |
Deskripsi
Barrett’s oesophagus is a precancerous intestinal metaplasia that can progress to oesophageal adenocarcinoma. In this study, the authors isolate and characterize human Barrett’s stem cells and identify a specific genomic pedigree that supports the potential role of these cells as precursors of oesophageal adenocarcinoma.