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Integrin beta 6 (ITGB6) is one of the important integrin family proteins, required for viral entry in their respective host. The constitutive expression of ITGB6 was reported in cattle and sheep but not in buffalo. The present study is first of its kind to characterize the constitutive expression pattern of ITGB6 in the air pathways of buffalo (Bubalus bubalis). In the present study, we characterized the constitutive expression pattern of ITGB6 in the air pathways of buffalo. Our data demonstrated that mRNA transcript and concentration of ITGB6 are significantly higher in tongue tissues compared to trachea, bronchi and lung. The study may highlight that oral mucosa of buffalo are enriched with integrin receptor genes, which are the target of certain viral entry site.