FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence
oleh: Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer, Elsa Logarinho
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-07-01 |
Deskripsi
Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that triggers permanent cell cycle arrest and full senescence.