Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist
oleh: Francois Moreau, Nicholas S. Kirk, Fa Zhang, Vasily Gelfanov, Edward O. List, Martina Chrudinová, Hari Venugopal, Michael C. Lawrence, Veronica Jimenez, Fatima Bosch, John J. Kopchick, Richard D. DiMarchi, Emrah Altindis, C. Ronald Kahn
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
The authors previously identified a family of viral insulin-like peptides (VILPs) with high homology to human insulin/IGF−1. Here, they report that one of these VILPs exhibits antagonist properties associated with a unique conformation of the IGF1R.