Homodimerized cytoplasmic domain of PD-L1 regulates its complex glycosylation in living cells
oleh: Li Zhou, Fangni Chai, Yong He, Zhihui Zhou, Shupan Guo, Pan Li, Qi Sun, Xueyin Zu, Xin Liu, Qin Huang, Yanping Zhong, Aolan Zhou, Xueyun Wang, Haiyan Ren
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-08-01 |
Deskripsi
Membrane-anchored PD-L1 homodimerizes in cells. N-glycosylation of PD-L1 regulates its homodimerization. The formation of PD-L1 homodimers further regulates their glycan processing, localization to the plasma membrane, and binding to PD-1.