Adrenergic stress constrains the development of anti-tumor immunity and abscopal responses following local radiation
oleh: Minhui Chen, Guanxi Qiao, Bonnie L. Hylander, Hemn Mohammadpour, Xiang-Yang Wang, John R. Subjeck, Anurag K. Singh, Elizabeth A. Repasky
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-04-01 |
Deskripsi
Abscopal responses in patients and preclinical models following radiation therapy are rare. Here the authors show that, in murine tumor models, reducing adrenergic stress or β2-adrenergic receptor signalling not only improves control of the irradiated tumor but significantly increases abscopal events.