Molecular pathways driven by ETO2-GLIS2 in aggressive pediatric leukemia
oleh: Cécile Thirant, Cécile Lopez, Sébastien Malinge, Thomas Mercher
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2017-11-01 |
Deskripsi
The ETO2-GLIS2 fusion oncoprotein is associated with poor prognosis pediatric acute megakaryoblastic leukemia. Recently, we observed that ETO2-GLIS2 controls enhancers activity at genes regulating haematopoietic progenitor self-renewal and differentiation toward the megakaryocytic lineage. We also showed that targeting ETO2-GLIS2 complex stability inhibits these properties and may represent a novel therapeutic strategy.