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Background: Oral submucous fibrosis (OSMF) is an insidious chronic inflammatory progressive disease and one of the potentially malignant disorders, predominantly affecting the oral cavity. Objective: The current study aimed to compare the efficacy of curcumin and aloe vera along with ultrasound in the management of OSMF. Materials and Methods: In this intervention study, 40 participants with OSMF were allocated into two groups. Group A included 20 patients who received curcumin (curenext) oral gel for 3 months along with ultrasound therapy. Group B included 20 patients who received aloe vera gel (forever living gel) along with ultrasound therapy. Results: Following therapies, patients in the group A showed clinically significant improvements when compared to group B. Conclusion: The combined therapy of curcumin and ultrasound shows potential in managing OSMF by effectively alleviating clinical symptoms without any reported side effects. It is advised that future studies employ larger samples and longer treatment follow-up.