Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes
oleh: Elise Ishida, Devin T. Corrigan, Ryan J. Malonis, Daniel Hofmann, Tingting Chen, Anita G. Amin, Delphi Chatterjee, Maju Joe, Todd L. Lowary, Jonathan R. Lai, Jacqueline M. Achkar
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-10-01 |
Deskripsi
Elise Ishida et al. generate human monoclonal antibodies that can selectively recognize specific oligosaccharide epitopes of the polysaccharides arabinomannan and lipoarabinomannan, which are critical for M. tuberculosis pathogenesis. The authors demonstrate the utility of these antibodies in both diagnostic and laboratory settings, making them important tools for M. tuberculosis research.