LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
oleh: Julie Brind’Amour, Hisato Kobayashi, Julien Richard Albert, Kenjiro Shirane, Akihiko Sakashita, Asuka Kamio, Aaron Bogutz, Tasuku Koike, Mohammad M. Karimi, Louis Lefebvre, Tomohiro Kono, Matthew C. Lorincz
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.