Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
за авторством: Gijeong Kim, Liyana Azmi, Seongmin Jang, Taeyang Jung, Hans Hebert, Andrew J. Roe, Olwyn Byron, Ji-Joon Song
| Формат: | Article |
|---|---|
| Опубліковано: | Nature Portfolio 2019-10-01 |
Опис
Aldehyde-alcohol dehydrogenase (AdhE) converts acetyl-CoA to ethanol and plays an important role in bacterial fermentation. Here the authors present the 3.5 Å cryo-EM structure of full-length E. coli AdhE, which reveals a right-handed helical spirosome structure and they show that the helical structure is required for AdhE activity.