Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations
oleh: Agnese Loda, Johannes H. Brandsma, Ivaylo Vassilev, Nicolas Servant, Friedemann Loos, Azadeh Amirnasr, Erik Splinter, Emmanuel Barillot, Raymond A. Poot, Edith Heard, Joost Gribnau
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
Xist RNA is required for X chromosome inactivation but it is not well understood how Xist silences some regions more efficiently than others. Here, the authors induce ectopic Xist expression from multiple different X-linked and autosomal loci in cells to explore Xist function.