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The survival rate for head and neck cancer patients has not substantially changed in the last two decades. We previously showed that two rV-<i>neu</i>T intratumoral injections induced an efficient antitumor response and rejection of transplanted Neu (rat <i>ErbB2/neu</i> oncogene-encoded protein)-overexpressing salivary gland tumor cells in BALB-<i>neu</i>T mice (BALB/c mice transgenic for the rat <i>ErbB2/neu</i> oncogene). However, reiterated poxviral vaccinations increase neutralizing antibodies to viral proteins in humans that prevent immune response against the recombinant antigen expressed by the virus. Curcumin (CUR) is a polyphenol with antineoplastic and immunomodulatory properties. The aim of this study was to employ CUR administration to boost the anti-Neu immune response and anticancer activity induced by one rV-<i>neu</i>T intratumoral vaccination in BALB-<i>neu</i>T mice. Here, we demonstrated that the combined rV-n<i>eu</i>T+CUR treatment was more effective at reducing tumor growth and increasing mouse survival, anti-Neu humoral response, and IFN-γ/IL-2 T-cell release in vitro than the individual treatment. rV-<i>neu</i>T+CUR-treated mice showed an increased infiltration of CD4⁺/CD8⁺ T lymphocytes within the tumor as compared to those that received the individual treatment. Overall, CUR enhanced the antitumoral effect and immune response to Neu induced by the rV-<i>neu</i>T vaccine in mice. Thus, the combined treatment might represent a successful strategy to target ErbB2/Neu-overexpressing tumors.