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The study evaluates the influence of irrigation with sodium hypochlorite on the microtensile bond strength to dentin with different bonding protocols on pre-endodontic restorations. After endodontic opening of restored human molars, teeth were randomly divided into four experimental groups: group 1 was not irrigated and the access was restored, while the other groups were irrigated with sodium hypochlorite. Group 2 was restored, group 3 had the endodontic access walls instrumented, and group 4 had CoJet sandblasting and silane application prior to final restoration. The bond strength after irrigation showed higher values when silicatization is performed.