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An efficient synthesis of a new series of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole derivatives from the reaction of 3-hydroxypyrrole, malononitrile, and various aromatic aldehydes using ZrOCl2·8H2O, an environmentally friendly catalyst under a thermal solvent-free green procedure is described. This simple protocol offer advantages such as shorter reaction times, simple work-up and excellent yield. The catalyst ZrOCl2·8H2O can be reused. The reusability of the catalyst has been studied for the synthesis of 5-amino-7-aryl-6-cyano-4H-pyrano[3,2-b]pyrrole. All the compounds were screened for their antibacterial and antifungal activity. DOI:http://dx.doi.org/10.4314/bcse.v28i1.11