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Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks
oleh: Holly A. Rees, Wei-Hsi Yeh, David R. Liu
Format: | Article |
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Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
Here the authors fuse hRad51 and variants thereof to Cas9 nickase to facilitate homology-directed repair without generating double strand breaks, minimizing indel formation and off-target editing. This tool represents progress towards the goal of performing HDR without an excess of undesired side products.