Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells
oleh: Manuel D. Díaz-Muñoz, Vladimir Yu. Kiselev, Nicolas Le Novère, Tomaz Curk, Jernej Ule, Martin Turner
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent manner.