Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
A Point Cloud-Based Deep Learning Model for Protein Docking Decoys Evaluation
oleh: Ye Han, Simin Zhang, Fei He
Format: | Article |
---|---|
Diterbitkan: | MDPI AG 2023-04-01 |
Deskripsi
Protein-protein docking reveals the process and product in protein interactions. Typically, a protein docking works with a docking model sampling, and then an evaluation method is used to rank the near-native models out from a large pool of generated decoys. In practice, the evaluation stage is the bottleneck to perform accurate protein docking. In this paper, PointNet, a deep learning algorithm based on point cloud, is applied to evaluate protein docking models. The proposed architecture is able to directly learn deep representations carrying the geometrical properties and atomic attributes from the 3D structural data of protein decoys. The experimental results show that the informative representations can benefit our proposed method to outperform other algorithms.