Endogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
oleh: Carmen Corciulo, Matin Lendhey, Tuere Wilder, Hanna Schoen, Alexander Samuel Cornelissen, Gregory Chang, Oran D. Kennedy, Bruce N. Cronstein
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-05-01 |
Deskripsi
Osteoarthritis (OA) is a debilitating and destructive joint disease for which disease modifying drugs are not available. Here the authors show that extracellular adenosine signalling via the A2AR receptor on chondrocytes is needed to prevent OA and that liposome-bound adenosine injection can treat the pathology in rats.