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A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid
oleh: Keith G. Andrews, Radmila Faizova, Ross M. Denton
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-06-01 |
Deskripsi
Amino and trifluoromethyl groups are ubiquitous within medicinal chemistry, but synthesis of fluoroalkylamines normally requires harsh conditions or sensitive reagents. Here the authors report an operationally simple, catalyst-free procedure for the trifluoroethylation of primary and secondary amines.