A practical and catalyst-free trifluoroethylation reaction of amines using trifluoroacetic acid

oleh: Keith G. Andrews, Radmila Faizova, Ross M. Denton

Format: Article
Diterbitkan: Nature Portfolio 2017-06-01

Deskripsi

Amino and trifluoromethyl groups are ubiquitous within medicinal chemistry, but synthesis of fluoroalkylamines normally requires harsh conditions or sensitive reagents. Here the authors report an operationally simple, catalyst-free procedure for the trifluoroethylation of primary and secondary amines.