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In this review article are described different ways in which pesticides may disrupt human’s body system, various functions, and in particular of children, men, and women exposures. Pesticides are of vital importance in fight against crop diseases, for production and storage of food, and widely used for pest control in agriculture, gardening, homes, and soil treatment. Most common factors contributing to illness are excessive insecticide application, failure to wash pesticide-treated bedding, and inadequate notification of pesticide application. Majority of insecticide exposures are to pyrethroids, pyrethrins, or many others, and most frequently reported health-impacted outcomes are neurologic symptoms including headache and dizziness, respiratory symptoms including upper respiratory tract pain and irritation and dyspnea, and gastrointestinal symptoms including nausea and vomiting. Some pesticides may interfere with male and female hormonal functions, which may lead to negative effects on reproductive system through disruption of hormonal balance necessary for proper body functioning. Previous studies primarily focused on interference with estrogen and androgen receptor; however, hormonal function may be disrupted in many more ways through pesticide exposure. Parental exposure to pesticides has been linked with birth defects in children, and studies suggest that pesticides may compromise the immune system of infants and children. Every effort should be made to limit children, men, and women exposures to pesticides including educating of public about effective vector management. Furthermore, house holders should have to take into account that dose, timing, and duration of exposure are critical to the ability of a pesticide to cause harmful effects.