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A chec klist of the Melastomataceae of Equatorial Guinea is presented with 57 taxa. Three species were accepted based only on literature records, their distribution área strongly suggests their presence in Equatorial Guinea. Six species are known from Annobón, 23 from Bioko and 49 from Río Muni. Best-represented genera are Memecylon (10), Calvoa (10) and Tristemma (7). Twenty-six taxa are newly recorded for the country. Heterotis obamae Lejoly & Lisowski is set in synonymy with the previously described Heterotis arenaria Jacq.-Fél.