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Coronavirus Disease-2019 (COVID-19) vaccine acceptance is variable. We surveyed participants in the COVID-19 Community Research Partnership from 17 December 2020 to 13 January 2021 to assess vaccine receptiveness. Vaccine uptake was then monitored until 15 May 2021; 20,232 participants responded to the receptiveness survey with vaccination status accessed in 18,874 participants via daily follow-up surveys (participants not completing daily surveys ≥30 days to 15 May 2021, were excluded). In the initial survey, 4802 (23.8%) were vaccine hesitant. Hesitancy was most apparent in women (Adjusted RR 0.93, <i>p</i> < 0.001), Black Americans (Adjusted RR 1.39, 1.41, 1.31 to non-Hispanic Whites, Other, and Hispanic or Latino, respectively <i>p</i> < 0.001), healthcare workers (Adjusted RR 0.93, <i>p</i> < 0.001), suburbanites (ref. Urban Adjusted RR 0.85, 0.90 to urban and rural dwellers, respectively, <i>p</i> < 0.01), and those previously diagnosed with COVID-19 (RR 1.20, <i>p</i> < 0.01). Those <50 years were also less accepting of vaccination. Subsequent vaccine uptake was 99% in non-hesitant participants. For those who were unsure, preferred not to answer, or answered “no”, vaccination rates were 80% (Adjusted RR 0.86, <i>p</i> < 0.0001), 78% (Adjusted RR 0.83, <i>p</i> < 0.0001), and 52.7% (Adjusted RR 0.65, <i>p</i> < 0.0001), respectively. These findings suggest that initial intent did not correlate with vaccine uptake in our cohort.