Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions
oleh: Hyunjin Jung, Seong-Wook Kim, Minsoo Kim, Jongryul Hong, Daseuli Yu, Ji Hye Kim, Yunju Lee, Sungsoo Kim, Doyeon Woo, Hee-Sup Shin, Byung Ouk Park, Won Do Heo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
Most approaches to control gene expression in vivo require generation of knock-in mouse lines and often lack spatiotemporal control. Here the authors develop a photo-activatable Flp recombinase system and demonstrate its use by controlling object-exploration behavior in mice through Cav3.1 silencing.