DL4-μbeads induce T cell lineage differentiation from stem cells in a stromal cell-free system
oleh: Ashton C. Trotman-Grant, Mahmood Mohtashami, Joshua De Sousa Casal, Elisa C. Martinez, Dylan Lee, Sintia Teichman, Patrick M. Brauer, Jianxun Han, Michele K. Anderson, Juan Carlos Zúñiga-Pflücker
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-08-01 |
Deskripsi
T cells derived from stem cells can be harnessed for regenerative medicine and cancer immunotherapy, but current technologies limit production and translation. Here, the authors present a serum-free, stromal-cell free DLL4-coated microbead method for the scalable production of T-lineage cells from multiple sources of stem cells.