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Atopic Dermatitis (AD) or eczema is a chronic and relapsing, itchy skin inflammatory condition in infancy and childhood. The diagnosis is based on pruritus and an eczematous dermatitis with typical presentation. A five-month-old infant who was suffering from itches and eczema since three months, was diagnosed with AD. After clinical diagnosis of AD, the condition seemed to be superimposed by a bacterial infection, an empirical treatment of antibiotic (oral cephalexin) was started. However, the patient showed no improvement. As per the hospital protocol, he received clindamycin, to which the lesions responded and totally resolved. The AD in our case was reported due to severe facial impetigo with an unusual feature that it resembled a primary immunodeficiency. However, in our case, the patient had an intact immune system and did not have any transient hypogammaglobulinemia.