Carvedilol targets β-arrestins to rewire innate immunity and improve oncolytic adenoviral therapy
oleh: Joseph I. Hoare, Bleona Osmani, Emily A. O’Sullivan, Ashley Browne, Nicola Campbell, Stephen Metcalf, Francesco Nicolini, Jayeta Saxena, Sarah A. Martin, Michelle Lockley
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-02-01 |
Deskripsi
Hoare et al describe a drug-repurposing approach and report that carvedilol, a β-arrestin-biased β-blocker, exhibits synergistic anti-ovarian cancer effects with oncolytic adenovirus. The study reveals that carvedilol augments the activity of oncolytic adenoviruses via β-arrestins to re-wire cytokine networks and innate immunity, resulting in increased oncolytic activity.