A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers
oleh: Gourish Mondal, Meredith Stevers, Benjamin Goode, Alan Ashworth, David A. Solomon
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
Cohesin complex mediates cohesion of sister chromatids and DNA loop formation. Here the authors show another role of cohesin in replication fork progression, suggesting a potential therapeutic strategy for cohesin-mutant cancers.