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<p>Pumilio2 (Pum2) is one of the newly discovered transcription regulatory factors in recent years, which exhibits similar function to microRNA (miRNA). Pumilio2 hinders the formation of translation initiation complexes and represses target gene expression from the combination of its specific structure domain with mRNA. Recent studies suggest that Pumilio2 is closely related to the morphogenesis and function of central nervous system. The different expression levels of Pumilio2 are involved in various biological processes of central nervous system diseases. This article mainly reviews the research progress of Pumilio2 and its role in central nervous system.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.12.005</p>