Direct PIP2 binding mediates stable oligomer formation of the serotonin transporter

oleh: Andreas Anderluh, Tina Hofmaier, Enrico Klotzsch, Oliver Kudlacek, Thomas Stockner, Harald H. Sitte, Gerhard J. Schütz

Format: Article
Diterbitkan: Nature Portfolio 2017-01-01

Deskripsi

The human serotonin transporter (SERT) mediates the uptake of neurotransmitters to terminate neuronal signalling. Here the authors use single-molecule imaging to get insight into the molecular origin of SERT oligomerization and their pre-set stoichiometry at the plasma membrane.