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Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations
oleh: Nafisur Rahman, Asma Khatoon, Habibur Rahman
Format: | Article |
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Diterbitkan: | Sociedade Brasileira de Química 2012-01-01 |
Deskripsi
A spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formation of ion-pair complex. Beer's law was obeyed in the concentration range of 2.0-9.0 µg mL-1 with molar absorptivity of 2.67 × 10(4) L mol-1 cm-1. The detection limit was found to be 0.18 µg mL-1. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.