Brain MR Spectroscopy in Autism Spectrum Disorder- the GABA excitatory/inhibitory imbalance theory revisited
oleh: Maiken Kirkegaard Brix, Maiken Kirkegaard Brix, Lars eErsland, Lars eErsland, Kenneth eHugdahl, Kenneth eHugdahl, Kenneth eHugdahl, Kenneth eHugdahl, Renate eGrüner, Renate eGrüner, Renate eGrüner, Maj-Britt ePosserud, Åsa eHammar, Alexander R Craven, Alexander R Craven, Ralph eNoeske, C. John eEvans, Hanne Bjørg eWalker, Tore eMidtvedt, Mona K Beyer, Mona K Beyer
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2015-06-01 |
Deskripsi
Magnetic resonance spectroscopy (MRS) from voxels placed in the left anterior cingulate cortex was measured from 14 boys with Autism Spectrum Disorder (ASD) and 24 gender and age-matched typically developing (TD) control group. Our main aims were to compare the concentration of γ-aminobutyric acid (GABA) between the two groups, and to investigate the relationship between brain metabolites and autism symptom severity in the ASD group. We did find a significant negative correlation in the ASD group between Autism Spectrum Screening Questionnaire (ASSQ) and GABA+/Cr, which may imply that severity of symptoms in ASD is associated with differences in the level of GABA in the brain, supporting the excitatory/inhibitory (E/I) imbalance theory. However we did not find a significant difference between the two groups in GABA levels.