MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer
oleh: Chiara Turco, Gabriella Esposito, Alessia Iaiza, Frauke Goeman, Anna Benedetti, Enzo Gallo, Theodora Daralioti, Letizia Perracchio, Andrea Sacconi, Patrizia Pasanisi, Paola Muti, Claudio Pulito, Sabrina Strano, Zaira Ianniello, Alessandro Fatica, Mattia Forcato, Francesco Fazi, Giovanni Blandino, Giulia Fontemaggi
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-06-01 |
Deskripsi
The circular isoform of VEGFA mRNA (circ_0076611), associated with size and pathogenesis of triple-negative breast tumors, is produced via back splicing of exon-7 by a RNP complex comprising lncRNA-MALAT1, ID4 and SRSF1, and secreted through exosomes.