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Early diagnosis and adequate treatment are main components in prophylaxis of osteoporosis and ruptures. We examined 8578 postmenopausal and elderly women for osteoporosis. A total of 26084 examinations were made: x-ray absorptiometry, bone ultrasonometry, DEXA of low spine bones and proximal bone for mineral density led us to the conclusion that it is necessary to make regular prophylactic examinations of 45-50-year-old women in peri- and postmenopause with following monitoring on demand for detection of initial signs of systemic osteopenia.