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To solve the optimization problem of edge distance in titanium alloy sheet during a new aircraft development stage,a three dimensional FE model was built on ABAQUS platfom. The effect of edge distance on residual stress distribution was analysised with TC4 titanium alloy by interference-fit strengthening technique under cylic loading. The study indicates that a considerble reduction of fatigue life is found with a lower egde distance ratio（ L/D）,also,the location of fatigue damage is moving against the hole. Fatigue damage happens in the margin part with edge distance ratio（ L/D） less than 2.