Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes
oleh: Rahul S. Kathayat, Yang Cao, Pablo D. Elvira, Patrick A. Sandoz, María-Eugenia Zaballa, Maya Z. Springer, Lauren E. Drake, Kay F. Macleod, F. Gisou van der Goot, Bryan C. Dickinson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-01-01 |
Deskripsi
S-palmitoylation regulation has been studied mostly in the cytosol and its role in mitochondria is unclear. Here the authors develop fluorescent mitochondria-targeted probes and find that depalmitoylation occurs in mitochondria and it’s influenced by alterations in mitochondrial lipid homeostasis.