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<strong>Objective-</strong> In diabetes impaired wound healing and other tissue abnormalities are considered as major concerns. The novel therapeutic options for treatment of wound in diabetic patients are urgently needed. The aim of the present study was to assess beneficial effects of chitosan nanocurcumin biofilm on healing of full thickness excisional wounds in diabetic rats.<br /><strong>Design-</strong> Experimental Study<br /><strong>Animals-</strong> Forty male diabetic Wistar rats<br /><strong>Procedures-</strong> The animals were randomized into four groups of ten animals each. Induction of diabetes was achieved using 60 mg/kg streptozotocin. In group I, 0.1 mL sterile saline 0.9% solution was added to the wounds with no dressing. In group II, the wounds were dressed with chitosan thin-film membranes. In group III, the wounds were treated with curcumin nanoparticles. In group IV, animals with were dressed with chitosan nanocurcumin biofilm. <br /><strong>Results-</strong> Planimetric, histological and quantitative morphometric studies and determination of hydroxyproline levels showed that there was significant difference between animals in group IV compared to other groups (<em>p</em> = 0.001). <br /><strong>Conclusion and clinical relevance-</strong> Chitosan nanocurcumin biofilm improved healing of diabetic wound in rats