Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses
oleh: Jonathan X. Meng, Yu Zhang, Dominik Saman, Arshad M. Haider, Suman De, Jason C. Sang, Karen Brown, Kun Jiang, Jane Humphrey, Linda Julian, Eric Hidari, Steven F. Lee, Gabriel Balmus, R. Andres Floto, Clare E. Bryant, Justin L. P. Benesch, Yu Ye, David Klenerman
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-05-01 |
Deskripsi
In this work, the authors report that hyperphosphorylated recombinant tau spontaneously assembles into small, amorphous aggregates, which disrupt membranes and induce Toll-like receptor 4-dependent responses in human macrophages.