FAM13A affects body fat distribution and adipocyte function
oleh: Mohsen Fathzadeh, Jiehan Li, Abhiram Rao, Naomi Cook, Indumathi Chennamsetty, Marcus Seldin, Xiang Zhou, Panjamaporn Sangwung, Michael J. Gloudemans, Mark Keller, Allan Attie, Jing Yang, Martin Wabitsch, Ivan Carcamo-Orive, Yuko Tada, Aldons J. Lusis, Myung Kyun Shin, Cliona M. Molony, Tracey McLaughlin, Gerald Reaven, Stephen B. Montgomery, Dermot Reilly, Thomas Quertermous, Erik Ingelsson, Joshua W. Knowles
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-03-01 |
Deskripsi
Genetic variants in the FAM13A locus have been associated with anthropometric and glycemic traits. Here, using fine-mapping, in vitro knockdown studies in pre-adipocytes and in vivo knockout in mice, the authors show that FAM13A is involved in regulating fat distribution and metabolic traits.