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Waste represents a cost for companies, in particular for agro-food companies, which can become a resource as a secondary material. In this work, we examine three products of olive-oil waste water, named <b>MOMAST^®</b> (<b>Plus30</b>, <b>PW25</b>, and <b>HY100</b>). Based on the chemical composition, obtained with different methods, we hypothesized a possible application as food supplements in irritable bowel syndrome (IBS). We therefore studied <b>MOMASTs</b> on some targets linked to this pathology: antioxidant action and spontaneous and induced intestinal contractility of the ileum and colon. <b>Plus30</b>, which showed a more promising biological of activity also for its oleuropein content, was characterized by an interesting action against some microorganisms. The results highlighted the ability of <b>Plus30</b> to modulate spontaneous and induced contractility, to exert a good antioxidant action, and to significantly act on various microorganisms. These effects are synergistic in the presence of antibiotics. In conclusion, we can confirm that <b>Plus30</b> could be a great candidate as a food supplement in patients with IBS.