Mild SARS-CoV-2 Infection After Gene Therapy in a Child With Wiskott-Aldrich Syndrome: A Case Report
oleh: Sabina Cenciarelli, Sabina Cenciarelli, Valeria Calbi, Valeria Calbi, Federica Barzaghi, Federica Barzaghi, Maria Ester Bernardo, Maria Ester Bernardo, Maria Ester Bernardo, Chiara Oltolini, Maddalena Migliavacca, Maddalena Migliavacca, Vera Gallo, Vera Gallo, Francesca Tucci, Francesca Tucci, Federico Fraschetta, Federico Fraschetta, Elena Albertazzi, Elena Sophia Fratini, Elena Sophia Fratini, Giulia Consiglieri, Giulia Consiglieri, Stefania Giannelli, Francesca Dionisio, Claudia Sartirana, Sara Racca, Chiara Camesasca, Giovanni Peretto, Giovanni Peretto, Rita Daverio, Antonio Esposito, Antonio Esposito, Francesco De Cobelli, Francesco De Cobelli, Paolo Silvani, Marco Rabusin, Andrea Cara, Daria Trabattoni, Stefania Dispinseri, Gabriella Scarlatti, Lorenzo Piemonti, Vito Lampasona, Maria Pia Cicalese, Maria Pia Cicalese, Alessandro Aiuti, Alessandro Aiuti, Alessandro Aiuti, Francesca Ferrua, Francesca Ferrua
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2020-11-01 |
Deskripsi
In this work we present the case of SARS-CoV-2 infection in a 1.5-year-old boy affected by severe Wiskott-Aldrich Syndrome with previous history of autoinflammatory disease, occurring 5 months after treatment with gene therapy. Before SARS-CoV-2 infection, the patient had obtained engraftment of gene corrected cells, resulting in WASP expression restoration and early immune reconstitution. The patient produced specific immunoglobulins to SARS-CoV-2 at high titer with neutralizing capacity and experienced a mild course of infection, with limited inflammatory complications, despite pre-gene therapy clinical phenotype.