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Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study
oleh: Larissa Nixdorf, Lukas Hartl, Stefanie Ströhl, Daniel Moritz Felsenreich, Magdalena Mairinger, Julia Jedamzik, Paula Richwien, Behrang Mozayani, Georg Semmler, Lorenz Balcar, Michael Schwarz, Mathias Jachs, Nina Dominik, Christoph Bichler, Michael Trauner, Mattias Mandorfer, Thomas Reiberger, Felix B. Langer, David Josef Maria Bauer, Gerhard Prager
Format: | Article |
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Diterbitkan: | Nature Portfolio 2024-07-01 |
Deskripsi
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) and related steatohepatitis (MASH) are common among obese patients and may improve after metabolic/bariatric surgery (MBS). 93 Patients undergoing MBS in 2021–2022 were prospectively enrolled. Liver stiffness measurement (LSM; via vibration-controlled transient elastography [VCTE], point [pSWE] and 2D [2DSWE] shear wave elastography) and non-invasive steatosis assessment (via controlled attenuation parameter [CAP]) were performed before (baseline [BL]) and three months (M3) after surgery. 93 patients (median age 40.9 years, 68.8% female, median BL-BMI: 46.0 kg/m2) were included. BL-liver biopsy showed MASLD in 82.8% and MASH in 34.4% of patients. At M3 the median relative total weight loss (%TWL) was 20.1% and the median BMI was 36.1 kg/m2. LSM assessed by VCTE and 2DSWE, as well as median CAP all decreased significantly from BL to M3 both in the overall cohort and among patients with MASH. There was a decrease from BL to M3 in median levels of ALT (34.0 U/L to 31 U/L; p = 0.025), gamma glutamyl transferase (BL: 30.0 to 21.0 U/L; p < 0.001) and MASLD fibrosis score (BL: − 0.97 to − 1.74; p < 0.001). Decreasing LSM and CAP, as well as liver injury markers suggest an improvement of MASLD/MASH as early as 3 months after MBS.